Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor

We have mapped a Jagged/Serrate-binding site to specific residues within the 12th EGF domain of human and Drosophila Notch. Two critical residues, involved in a hydrophobic interaction, provide a ligand-binding platform and are adjacent to a Fringe-sensitive residue that modulates Notch activity. Ou...

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Hauptverfasser: Whiteman, Pat, de Madrid, Beatriz Hernandez, Taylor, Paul, Li, Demin, Heslop, Rebecca, Viticheep, Nattnee, Tan, Joyce Zi, Shimizu, Hideyuki, Callaghan, Juliana, Masiero, Massimo, Li, Ji Liang, Banham, Alison H., Harris, Adrian L., Lea, Susan M., Redfield, Christina, Baron, Martin, Handford, Penny A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591638/
https://ncbi.nlm.nih.gov/pubmed/23339193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.428854
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