Development of therapeutic anti-JAGGED1 antibodies for cancer therapy

The role of Notch signaling and its ligand JAGGED1 (JAG1) in tumor biology have been firmly established, making them appealing therapeutic targets for cancer treatment. Here we report the development and characterization of human/rat-specific JAG1-neutralizing monoclonal antibodies. Epitope mapping...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Masiero, Massimo, Li, Demin, Whiteman, Pat, Bentley, Carol, Greig, Jenny, Hassanali, Tasneem, Watts, Sarah, Stribbling, Stephen, Yates, Jenna, Bealing, Ellen, Li, Ji-Liang, Chillakuri, Chandramouli, Sheppard, Devon, Serres, Sébastien, Sarmiento-Soto, Manuel, Larkin, James, Sibson, Nicola R., Handford, Penny A., Harris, Adrian L., Banham, Alison H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611158/
https://ncbi.nlm.nih.gov/pubmed/31395687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1176
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