Engineering chimeric human and mouse major histocompatibility complex (MHC) class I tetramers for the production of T-cell receptor (TCR) mimic antibodies

Therapeutic monoclonal antibodies targeting cell surface or secreted antigens are among the most effective classes of novel immunotherapies. However, the majority of human proteins and established cancer biomarkers are intracellular. Peptides derived from these intracellular proteins are presented o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Li, Demin, Bentley, Carol, Yates, Jenna, Salimi, Maryam, Greig, Jenny, Wiblin, Sarah, Hassanali, Tasneem, Banham, Alison H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407768/
https://ncbi.nlm.nih.gov/pubmed/28448627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176642
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