Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies

The Notch receptor is a key component of a core metazoan signaling pathway activated by Delta/Serrate/Lag-2 ligands expressed on an adjacent cell. This results in a short-range signal with profound effects on cell-fate determination, cell proliferation, and cell death. Key to understanding receptor...

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Vydáno v:Structure
Hlavní autoři: Weisshuhn, Philip C., Sheppard, Devon, Taylor, Paul, Whiteman, Pat, Lea, Susan M., Handford, Penny A., Redfield, Christina
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826273/
https://ncbi.nlm.nih.gov/pubmed/26996961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.02.010
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