Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands

The Notch pathway is a core cell-cell signaling system in metazoan organisms with key roles in cell-fate determination, stem cell maintenance, immune system activation, and angiogenesis. Signals are initiated by extracellular interactions of the Notch receptor with Delta/Serrate/Lag-2 (DSL) ligands,...

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Main Authors: Chillakuri, Chandramouli R., Sheppard, Devon, Ilagan, Ma. Xenia G., Holt, Laurie R., Abbott, Felicity, Liang, Shaoyan, Kopan, Raphael, Handford, Penny A., Lea, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888931/
https://ncbi.nlm.nih.gov/pubmed/24239355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.10.029
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