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The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

Notch signaling regulates many aspects of metazoan development and tissue renewal. Accordingly, misregulation or loss of Notch signaling underlies multiple human disorders, from developmental syndromes to adult onset diseases and cancer. Notch receptor activation is irreversible as it involves prote...

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Detalhes bibliográficos
Main Authors: Kopan, Raphael, Ilagan, Ma. Xenia G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827930/
https://ncbi.nlm.nih.gov/pubmed/19379690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.03.045
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