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The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

Notch signaling regulates many aspects of metazoan development and tissue renewal. Accordingly, misregulation or loss of Notch signaling underlies multiple human disorders, from developmental syndromes to adult onset diseases and cancer. Notch receptor activation is irreversible as it involves prote...

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Autors principals: Kopan, Raphael, Ilagan, Ma. Xenia G.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827930/
https://ncbi.nlm.nih.gov/pubmed/19379690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.03.045
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