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Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype
Recombinant canine B-domain deleted (BDD) factor VIII (FVIII) is predominantly expressed as a single-chain protein and exhibits greater stability after activation compared with human FVIII-BDD. We generated a novel BDD-FVIII variant (FVIII-RH) with an amino acid change at the furin cleavage site wit...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3663432/ https://ncbi.nlm.nih.gov/pubmed/23372167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-10-464164 |
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