Design and characterization of an APC-specific serpin for the treatment of hemophilia

Hemophilia is a bleeding disorder caused by deficiency in factors VIII or IX, the two components of the intrinsic Xase complex. Treatment with replacement factor can lead to the development of inhibitory antibodies, requiring the use of bypassing agents such as factor VIIa and factor concentrates. A...

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Bibliografski detalji
Izdano u:Blood
Glavni autori: Polderdijk, Stéphanie G. I., Adams, Ty E., Ivanciu, Lacramioara, Camire, Rodney M., Baglin, Trevor P., Huntington, James A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2017
Teme:
Thrombosis and Hemostasis
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5305054/
https://ncbi.nlm.nih.gov/pubmed/27789479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-05-718635
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