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Hemostatic agents of broad applicability produced by selective tuning of factor Xa zymogenicity
There is a clinical need to develop safe therapeutic strategies to mitigate bleeding. Previously, we found that a novel zymogen-like factor Xa variant (FXa-I16L) was effective in correcting the coagulation defect in hemophilic mice. Here we expand the mutational framework to tune the FX(a) zymogen-l...
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| Udgivet i: | Blood |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4492200/ https://ncbi.nlm.nih.gov/pubmed/25896653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-634329 |
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