Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Safe and effective antithrombotic therapy requires understanding of mechanisms that contribute to pathological thrombosis but have a lesser impact on hemostasis. We found that the extrinsic tissue factor (TF) coagulation initiation complex can selectively activate the antihemophilic cofactor, FVIII,...

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Bibliographic Details
Published in:Blood
Main Authors: Kamikubo, Yuichi, Mendolicchio, G. Loredana, Zampolli, Antonella, Marchese, Patrizia, Rothmeier, Andrea S., Orje, Jennifer Nagrampa, Gale, Andrew J., Krishnaswamy, Sriram, Gruber, András, Østergaard, Henrik, Petersen, Lars C., Ruf, Wolfram, Ruggeri, Zaverio M.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2017
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630012/
https://ncbi.nlm.nih.gov/pubmed/28729433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-767079
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