Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling

The tissue factor (TF) pathway serves both hemostasis and cell signaling, but how cells control these divergent functions of TF remains incompletely understood. TF is the receptor and scaffold of coagulation proteases cleaving protease-activated receptor 2 (PAR2) that plays pivotal roles in angiogen...

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Vydáno v:Blood
Hlavní autoři: Rothmeier, Andrea S., Liu, Enbo, Chakrabarty, Sagarika, Disse, Jennifer, Mueller, Barbara M., Østergaard, Henrik, Ruf, Wolfram
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805488/
https://ncbi.nlm.nih.gov/pubmed/29246902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-768218
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