EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice

Infection and inflammation are invariably associated with activation of the blood coagulation mechanism, secondary to the inflammation-induced expression of the coagulation initiator tissue factor (TF) on innate immune cells. By investigating the role of cell-surface receptors for coagulation factor...

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Publicado en:Blood
Autores principales: Liang, Hai Po H., Kerschen, Edward J., Hernandez, Irene, Basu, Sreemanti, Zogg, Mark, Botros, Fady, Jia, Shuang, Hessner, Martin J., Griffin, John H., Ruf, Wolfram, Weiler, Hartmut
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2015
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424632/
https://ncbi.nlm.nih.gov/pubmed/25733582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-11-610717
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