Variable phenotypic penetrance of thrombosis in adult mice after tissue-selective and temporally controlled Thbd gene inactivation

Thrombomodulin (Thbd) exerts pleiotropic effects on blood coagulation, fibrinolysis, and complement system activity by facilitating the thrombin-mediated activation of protein C and thrombin-activatable fibrinolysis inhibitor and may have additional thrombin- and protein C (pC)-independent functions...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: van Mens, Thijs E., Liang, Hai-Po H., Basu, Sreemanti, Hernandez, Irene, Zogg, Mark, May, Jennifer, Zhan, Min, Yang, Qiuhui, Foeckler, Jamie, Kalloway, Shawn, Sood, Rashmi, Karlson, Caren Sue, Weiler, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600150/
https://ncbi.nlm.nih.gov/pubmed/28920104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017005058
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