A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C)

Activation of blood coagulation and endothelial inflammation are hallmarks of respiratory infections with RNA viruses that contribute significantly to the morbidity and mortality of patients with severe disease. We investigated how signaling by coagulation proteases affects the quality and extent of...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Subramaniam, Saravanan, Ogoti, Yamini, Hernandez, Irene, Zogg, Mark, Botros, Fady, Burns, Robert, DeRousse, Jacob T., Dockendorff, Chris, Mackman, Nigel, Antoniak, Silvio, Fletcher, Craig, Weiler, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288670/
https://ncbi.nlm.nih.gov/pubmed/34242391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2021004360
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