A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C)

Activation of blood coagulation and endothelial inflammation are hallmarks of respiratory infections with RNA viruses that contribute significantly to the morbidity and mortality of patients with severe disease. We investigated how signaling by coagulation proteases affects the quality and extent of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood Adv
Prif Awduron: Subramaniam, Saravanan, Ogoti, Yamini, Hernandez, Irene, Zogg, Mark, Botros, Fady, Burns, Robert, DeRousse, Jacob T., Dockendorff, Chris, Mackman, Nigel, Antoniak, Silvio, Fletcher, Craig, Weiler, Hartmut
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2021
Pynciau:
Thrombosis and Hemostasis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288670/
https://ncbi.nlm.nih.gov/pubmed/34242391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2021004360
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