A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development

Tissue factor pathway inhibitor (TFPI) is a critical anticoagulant protein present in endothelium and platelets. Mice lacking TFPI (Tfpi(−/−)) die in utero from disseminated intravascular coagulation. They are rescued by concomitant tissue factor (TF) deficiency, demonstrating that TFPI modulates TF...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Ellery, Paul E. R., Maroney, Susan A., Cooley, Brian C., Luyendyk, James P., Zogg, Mark, Weiler, Hartmut, Mast, Alan E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481595/
https://ncbi.nlm.nih.gov/pubmed/25954015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-633958
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