Molecular Dynamics Simulations and Functional Characterization of the Interactions of the PAR2 Ectodomain with Factor VIIa

Signaling of the tissue factor-FVIIa complex regulates angiogenesis, tumor growth and inflammation. TF-FVIIa triggers cell signaling events by cleavage of protease activated receptor (PAR2) at the Arg36-Ser37 scissile bond. The recognition of PAR2 by the FVIIa protease domain is poorly understood. W...

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Hlavní autoři: Zhang, Qing, Petersen, Helle H., Ostergaard, Henrik, Ruf, Wolfram, Olson, Arthur J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913976/
https://ncbi.nlm.nih.gov/pubmed/19536895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22468
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