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Molecular Dynamics Simulations and Functional Characterization of the Interactions of the PAR2 Ectodomain with Factor VIIa
Signaling of the tissue factor-FVIIa complex regulates angiogenesis, tumor growth and inflammation. TF-FVIIa triggers cell signaling events by cleavage of protease activated receptor (PAR2) at the Arg36-Ser37 scissile bond. The recognition of PAR2 by the FVIIa protease domain is poorly understood. W...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913976/ https://ncbi.nlm.nih.gov/pubmed/19536895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22468 |
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