Engineering of Substrate Selectivity for Tissue Factor·Factor VIIa Complex Signaling through Protease-activated Receptor 2

The complex of factor VIIa (FVIIa) with tissue factor (TF) triggers coagulation by recognizing its macromolecular substrate factors IX (FIX) and X (FX) predominantly through extended exosite interactions. In addition, TF mediates unique cell-signaling properties in cancer, angiogenesis, and inflamma...

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Bibliographic Details
Main Authors: Larsen, Katrine S., Østergaard, Henrik, Olsen, Ole H., Bjelke, Jais R., Ruf, Wolfram, Petersen, Lars C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888407/
https://ncbi.nlm.nih.gov/pubmed/20388709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.101030
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