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Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa
The remarkably high specificity of the coagulation proteases towards macromolecular substrates is provided by numerous interactions involving the catalytic groove and remote exosites. For FVIIa [activated FVII (Factor VII)], the principal initiator of coagulation via the extrinsic pathway, several e...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2267294/ https://ncbi.nlm.nih.gov/pubmed/17456045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061901 |
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