Beating tissue factor at its own game: Design and properties of a soluble tissue factor–independent coagulation factor VIIa

Two decades of research have uncovered the mechanism by which the complex of tissue factor (TF) and the plasma serine protease factor VIIa (FVIIa) mediates the initiation of blood coagulation. Membrane-anchored TF directly interacts with substrates and induces allosteric effects in the protease doma...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Sorensen, Anders B., Tuneew, Inga, Svensson, L. Anders, Persson, Egon, Østergaard, Henrik, Overgaard, Michael Toft, Olsen, Ole H., Gandhi, Prafull S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956519/
https://ncbi.nlm.nih.gov/pubmed/31801825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009183
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