Engineering of a membrane-triggered activity switch in coagulation factor VIIa

Recombinant factor VIIa (FVIIa) variants with increased activity offer the promise to improve the treatment of bleeding episodes in patients with inhibitor-complicated hemophilia. Here, an approach was adopted to enhance the activity of FVIIa by selectively optimizing substrate turnover at the membr...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Nielsen, Anders L., Sorensen, Anders B., Holmberg, Heidi L., Gandhi, Prafull S., Karlsson, Johan, Buchardt, Jens, Lamberth, Kasper, Kjelgaard-Hansen, Mads, Ley, Carsten Dan, Sørensen, Brit B., Ruf, Wolfram, Olsen, Ole H., Østergaard, Henrik
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703266/
https://ncbi.nlm.nih.gov/pubmed/29109275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618713114
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