Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa

The remarkably high specificity of the coagulation proteases towards macromolecular substrates is provided by numerous interactions involving the catalytic groove and remote exosites. For FVIIa [activated FVII (Factor VII)], the principal initiator of coagulation via the extrinsic pathway, several e...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Larsen, Katrine S., Østergaard, Henrik, Bjelke, Jais R., Olsen, Ole H., Rasmussen, Hanne B., Christensen, Leif, Kragelund, Birthe B., Stennicke, Henning R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Portland Press Ltd. 2007
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267294/
https://ncbi.nlm.nih.gov/pubmed/17456045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061901
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