Mechanism of the Ca(2+)-induced Enhancement of the Intrinsic Factor VIIa Activity

The intrinsic activity of coagulation factor VIIa (FVIIa) is dependent on Ca(2+) binding to a loop (residues 210–220) in the protease domain. Structural analysis revealed that Ca(2+) may enhance the activity by attenuating electrostatic repulsion of Glu(296) and/or by facilitating interactions betwe...

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Detalhes bibliográficos
Main Authors: Bjelke, Jais R., Olsen, Ole H., Fodje, Michel, Svensson, L. Anders, Bang, Susanne, Bolt, Gert, Kragelund, Birthe B., Persson, Egon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258868/
https://ncbi.nlm.nih.gov/pubmed/18640965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800841200
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