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The length of the linker between the epidermal growth factor-like domains in factor VIIa is critical for a productive interaction with tissue factor
Formation of the factor VIIa (FVIIa)-tissue factor (TF) complex triggers the blood coagulation cascade. Using a structure-based rationale, we investigated how the length of the linker region between the two epidermal growth factor (EGF)-like domains in FVIIa influences TF binding and the allosteric...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4253812/ https://ncbi.nlm.nih.gov/pubmed/25234571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2553 |
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