Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa

The remarkably high specificity of the coagulation proteases towards macromolecular substrates is provided by numerous interactions involving the catalytic groove and remote exosites. For FVIIa [activated FVII (Factor VII)], the principal initiator of coagulation via the extrinsic pathway, several e...

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Bibliografische gegevens
Hoofdauteurs: Larsen, Katrine S., Østergaard, Henrik, Bjelke, Jais R., Olsen, Ole H., Rasmussen, Hanne B., Christensen, Leif, Kragelund, Birthe B., Stennicke, Henning R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Portland Press Ltd. 2007
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267294/
https://ncbi.nlm.nih.gov/pubmed/17456045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061901
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