Size regulation of von Willebrand factor–mediated platelet thrombi by ADAMTS13 in flowing blood

The metalloproteinase ADAMTS13 regulates the size of released von Willebrand factor (VWF) multimers bound to endothelial cells, but it is unknown whether it can cleave plasma VWF during thrombogenesis. To address this issue, we perfused blood over immobilized VWF and used videomicroscopy to visualiz...

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Detalhes bibliográficos
Main Authors: Donadelli, Roberta, Orje, Jennifer N., Capoferri, Cristina, Remuzzi, Giuseppe, Ruggeri, Zaverio M.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895707/
https://ncbi.nlm.nih.gov/pubmed/16293606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-07-2972
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