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N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity
Severe deficiency of ADAMTS13, a plasma metalloprotease, leads to thrombotic thrombocytopenic purpura. ADAMTS13 contains 10 putative N-glycosylation sites in or near its metalloprotease sequence, spacer region, thrombospondin type 1 repeat no. 4 (TSR no. 4), and CUB domains. Tunicamycin treatment ma...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630278/ https://ncbi.nlm.nih.gov/pubmed/18981290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-167775 |
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