Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13

Elevated plasma von Willebrand factor (VWF) and low ADAMTS13 activity have been reported in several inflammatory states, including sepsis and acute respiratory distress syndrome. One hallmark of inflammation is neutrophil activation and production of reactive oxygen species, including superoxide rad...

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Bibliografiske detaljer
Main Authors: Chen, Junmei, Fu, Xiaoyun, Wang, Yi, Ling, Minhua, McMullen, Brad, Kulman, John, Chung, Dominic W., López, José A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2010
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810979/
https://ncbi.nlm.nih.gov/pubmed/19812385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-213967
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