Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site

The function of von Willebrand factor (VWF) is regulated by proteolysis, which limits its multimeric size and ability to tether platelets. The importance of ADAMTS13 metalloprotease in VWF regulation is demonstrated by the association between severe deficiency of ADAMTS13 and thrombotic thrombocytop...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Raife, Thomas J., Cao, Wenjing, Atkinson, Bonnie S., Bedell, Bruce, Montgomery, Robert R., Lentz, Steven R., Johnson, George F., Zheng, X. Long
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2009
Pynciau:
Thrombosis and Hemostasis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731642/
https://ncbi.nlm.nih.gov/pubmed/19541819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-195461
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