Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site

The function of von Willebrand factor (VWF) is regulated by proteolysis, which limits its multimeric size and ability to tether platelets. The importance of ADAMTS13 metalloprotease in VWF regulation is demonstrated by the association between severe deficiency of ADAMTS13 and thrombotic thrombocytop...

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Hlavní autoři: Raife, Thomas J., Cao, Wenjing, Atkinson, Bonnie S., Bedell, Bruce, Montgomery, Robert R., Lentz, Steven R., Johnson, George F., Zheng, X. Long
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2009
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731642/
https://ncbi.nlm.nih.gov/pubmed/19541819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-195461
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