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Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site
The function of von Willebrand factor (VWF) is regulated by proteolysis, which limits its multimeric size and ability to tether platelets. The importance of ADAMTS13 metalloprotease in VWF regulation is demonstrated by the association between severe deficiency of ADAMTS13 and thrombotic thrombocytop...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2731642/ https://ncbi.nlm.nih.gov/pubmed/19541819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-195461 |
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