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An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers

Severe deficiency of ADAMTS13, a von Willebrand factor (VWF)–cleaving metalloprotease, causes thrombotic thrombocytopenic purpura. When analyzed with VWF multimers, but not with an abbreviated VWF peptide (VWF73) as the substrate, the plasma ADAMTS13 activity levels of mouse strains segregated into...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhou, Wenhua, Bouhassira, Eric E., Tsai, Han-Mou
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924774/
https://ncbi.nlm.nih.gov/pubmed/17426255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-070953
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