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An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers

Severe deficiency of ADAMTS13, a von Willebrand factor (VWF)–cleaving metalloprotease, causes thrombotic thrombocytopenic purpura. When analyzed with VWF multimers, but not with an abbreviated VWF peptide (VWF73) as the substrate, the plasma ADAMTS13 activity levels of mouse strains segregated into...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhou, Wenhua, Bouhassira, Eric E., Tsai, Han-Mou
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2007
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924774/
https://ncbi.nlm.nih.gov/pubmed/17426255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-070953
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