Hemolytic uremic syndrome–associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers

Shiga toxin 1 (Stx-1) and Stx-2 produced by enterohemorrhagic Escherichia coli cause the diarrhea-associated hemolytic uremic syndrome (HUS). This type of HUS is characterized by obstruction of the glomeruli and renal microvasculature by platelet-fibrin thrombi, acute renal failure, thrombocytopenia...

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Detalhes bibliográficos
Main Authors: Nolasco, Leticia H., Turner, Nancy A., Bernardo, Aubrey, Tao, Zhenyin, Cleary, Thomas G., Dong, Jing-fei, Moake, Joel L.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2005 by The American Society of Hematology 2005
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895236/
https://ncbi.nlm.nih.gov/pubmed/16131569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-2111
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