Cleavage of ultralarge multimers of von Willebrand factor by C-terminal–truncated mutants of ADAMTS-13 under flow

A disintegrin-like and metalloprotease with thrombospondin type 1-motif 13 (ADAMTS-13) cleaves the A2 domain of von Willebrand factor (VWF), converting the ultralarge (UL) and hyperactive VWF multimers freshly released from endothelial cells to smaller and less active forms found in plasma. Recombin...

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Autores principales: Tao, Zhenyin, Wang, Yongtao, Choi, Huiwei, Bernardo, Aubrey, Nishio, Kenji, Sadler, J. Evan, López, José A., Dong, Jing-fei
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Hematology 2005
Materias:
Hemostasis, Thrombosis, and Vascular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895119/
https://ncbi.nlm.nih.gov/pubmed/15774619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-11-4188
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