Cleavage of ultralarge multimers of von Willebrand factor by C-terminal–truncated mutants of ADAMTS-13 under flow

A disintegrin-like and metalloprotease with thrombospondin type 1-motif 13 (ADAMTS-13) cleaves the A2 domain of von Willebrand factor (VWF), converting the ultralarge (UL) and hyperactive VWF multimers freshly released from endothelial cells to smaller and less active forms found in plasma. Recombin...

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Detalhes bibliográficos
Main Authors: Tao, Zhenyin, Wang, Yongtao, Choi, Huiwei, Bernardo, Aubrey, Nishio, Kenji, Sadler, J. Evan, López, José A., Dong, Jing-fei
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895119/
https://ncbi.nlm.nih.gov/pubmed/15774619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-11-4188
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