Loading...

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

The metalloprotease ADAMTS13 efficiently cleaves only the Tyr(1605)-Met(1606) bond in the central A2 domain of multimeric von Willebrand factor (VWF), even though VWF constitutes only 0.02% of plasma proteins. This remarkable specificity depends in part on binding of the noncatalytic ADAMTS13 spacer...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Gao, Weiqiang, Anderson, Patricia J., Sadler, J. Evan
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518881/
https://ncbi.nlm.nih.gov/pubmed/18492952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-04-148759
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!