Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease

Von Willebrand factor (VWF) is a multimeric protein that mediates platelet adhesion at sites of vascular injury, and ADAMTS13 (a disintegrin and metalloprotease with thrombospondin)is a multidomain metalloprotease that limits platelet adhesion by a feedback mechanism in which fluid shear stress indu...

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Bibliographic Details
Main Authors: Gao, Weiqiang, Anderson, Patricia J., Majerus, Elaine M., Tuley, Elodee A., Sadler, J. Evan
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1681350/
https://ncbi.nlm.nih.gov/pubmed/17146059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607264104
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