Light Chain of Factor VIII Is Sufficient for Accelerating Cleavage of von Willebrand Factor by ADAMTS13 Metalloprotease

We previously demonstrated that coagulation factor VIII (FVIII) accelerates proteolytic cleavage of von Willebrand factor (VWF) by A disintegrin and metalloprotease with thrombospondin type 1 repeats (ADAMTS13) under fluid shear stress. In this study, the structural elements of FVIII required for th...

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Bibliographic Details
Main Authors: Cao, Wenjing, Sabatino, Denise E., Altynova, Ekaterina, Lange, Amy M., Casina, Veronica C., Camire, Rodney M., Zheng, X. Long
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463299/
https://ncbi.nlm.nih.gov/pubmed/22854959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.390690
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