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Light Chain of Factor VIII Is Sufficient for Accelerating Cleavage of von Willebrand Factor by ADAMTS13 Metalloprotease

We previously demonstrated that coagulation factor VIII (FVIII) accelerates proteolytic cleavage of von Willebrand factor (VWF) by A disintegrin and metalloprotease with thrombospondin type 1 repeats (ADAMTS13) under fluid shear stress. In this study, the structural elements of FVIII required for th...

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Autores principales: Cao, Wenjing, Sabatino, Denise E., Altynova, Ekaterina, Lange, Amy M., Casina, Veronica C., Camire, Rodney M., Zheng, X. Long
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463299/
https://ncbi.nlm.nih.gov/pubmed/22854959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.390690
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