Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13

Proteolytic processing of von Willebrand factor (VWF) by ADAMTS13 metalloproteinase is crucial for normal hemostasis. In vitro, cleavage of VWF by ADAMTS13 is slow even at high shear stress and is typically studied in the presence of denaturants. We now show that, under shear stress and at physiolog...

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Bibliographic Details
Main Authors: Cao, Wenjing, Krishnaswamy, Sriram, Camire, Rodney M., Lenting, Peter J., Zheng, X. Long
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396690/
https://ncbi.nlm.nih.gov/pubmed/18492805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801735105
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