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Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13
Proteolytic processing of von Willebrand factor (VWF) by ADAMTS13 metalloproteinase is crucial for normal hemostasis. In vitro, cleavage of VWF by ADAMTS13 is slow even at high shear stress and is typically studied in the presence of denaturants. We now show that, under shear stress and at physiolog...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2396690/ https://ncbi.nlm.nih.gov/pubmed/18492805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801735105 |
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