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Interaction of Shiga Toxin with the A-domains and Multimers of von Willebrand Factor

Shiga toxin (Stx) produced by enterohemorrhagic Escherichia coli causes diarrhea-associated hemolytic-uremic syndrome (DHUS), a severe renal thrombotic microangiopathy. We investigated the interaction between Stx and von Willebrand Factor (VWF), a multimeric plasma glycoprotein that mediates platele...

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Detalhes bibliográficos
Main Authors: Lo, Nathan C., Turner, Nancy A., Cruz, Miguel A., Moake, Joel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829160/
https://ncbi.nlm.nih.gov/pubmed/24097977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.487413
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