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Internal Tensile Force and A2 Domain Unfolding of von Willebrand Factor Multimers in Shear Flow
Using Brownian molecular dynamics simulations, we examine the internal dynamics and biomechanical response of von Willebrand factor (vWF) multimers subject to shear flow. The coarse grain multimer description employed here is based on a monomer model in which the A2 domain of vWF is explicitly repre...
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| Published in: | Biophys J |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Biophysical Society
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6303231/ https://ncbi.nlm.nih.gov/pubmed/30287111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.09.001 |
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