Internal Tensile Force and A2 Domain Unfolding of von Willebrand Factor Multimers in Shear Flow

Using Brownian molecular dynamics simulations, we examine the internal dynamics and biomechanical response of von Willebrand factor (vWF) multimers subject to shear flow. The coarse grain multimer description employed here is based on a monomer model in which the A2 domain of vWF is explicitly repre...

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Bibliographic Details
Published in:Biophys J
Main Authors: Morabito, Michael, Dong, Chuqiao, Wei, Wei, Cheng, Xuanhong, Zhang, Xiaohui F., Oztekin, Alparslan, Webb, Edmund
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2018
Subjects:
Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303231/
https://ncbi.nlm.nih.gov/pubmed/30287111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.09.001
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