Long-ranged Protein-glycan Interactions Stabilize von Willebrand Factor A2 Domain from Mechanical Unfolding

von Willebrand Factor (vWF) is a large multimeric protein that binds to platelets and collagen in blood clotting. vWF A2 domain hosts a proteolytic site for ADAMTS13 (A Disintegrin and Metalloprotease with a ThromboSpondin type 1 motif, member 13) to regulate the size of vWF multimers. This regulati...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Dong, Chuqiao, Lee, Jumin, Kim, Seonghoon, Lai, Whitney, Webb, Edmund B., Oztekin, Alparslan, Zhang, X. Frank, Im, Wonpil
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207679/
https://ncbi.nlm.nih.gov/pubmed/30375453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34374-y
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