Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress

We describe here the mechanism of platelet adhesion to immobilized von Willebrand factor (VWF) and subsequent formation of platelet-derived microparticles mediated by glycoprotein Ibα (GPIbα) under high shear stress. As visualized in whole blood perfused in a flow chamber, platelet attachment to VWF...

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Bibliografiske detaljer
Main Authors: Reininger, Armin J., Heijnen, Harry F. G., Schumann, Hannah, Specht, Hanno M., Schramm, Wolfgang, Ruggeri, Zaverio M.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Hematology 2006
Fag:
Hemostasis, Thrombosis, and Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895770/
https://ncbi.nlm.nih.gov/pubmed/16449527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-02-0618
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