Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress

We describe here the mechanism of platelet adhesion to immobilized von Willebrand factor (VWF) and subsequent formation of platelet-derived microparticles mediated by glycoprotein Ibα (GPIbα) under high shear stress. As visualized in whole blood perfused in a flow chamber, platelet attachment to VWF...

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Hlavní autoři: Reininger, Armin J., Heijnen, Harry F. G., Schumann, Hannah, Specht, Hanno M., Schramm, Wolfgang, Ruggeri, Zaverio M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society of Hematology 2006
Témata:
Hemostasis, Thrombosis, and Vascular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895770/
https://ncbi.nlm.nih.gov/pubmed/16449527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-02-0618
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