Functional self-association of von Willebrand factor during platelet adhesion under flow

We have used recombinant wild-type human von Willebrand factor (VWF) and deletion mutants lacking the A1 and A3 domains, as well as specific function-blocking monoclonal antibodies, to demonstrate a functionally relevant self-association at the interface of soluble and surface-bound VWF. Platelets p...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Savage, Brian, Sixma, Jan J., Ruggeri, Zaverio M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11756664/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012459599
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