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Functional self-association of von Willebrand factor during platelet adhesion under flow

We have used recombinant wild-type human von Willebrand factor (VWF) and deletion mutants lacking the A1 and A3 domains, as well as specific function-blocking monoclonal antibodies, to demonstrate a functionally relevant self-association at the interface of soluble and surface-bound VWF. Platelets p...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Savage, Brian, Sixma, Jan J., Ruggeri, Zaverio M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The National Academy of Sciences 2002
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC117576/
https://ncbi.nlm.nih.gov/pubmed/11756664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012459599
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