Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Production of recombinant B-domain–deleted canine factor VIII (cFVIII-BDD) unexpectedly revealed superior protein yields with 3-fold increased specific activity relative to human FVIII-BDD (hFVIII-BDD). We also determined that activated cFVIII-BDD is more stable than activated hFVIII-BDD. Furthermor...

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Autori principali: Sabatino, Denise E., Freguia, Christian Furlan, Toso, Raffaella, Santos, Andrey, Merricks, Elizabeth P., Kazazian, Haig H., Nichols, Timothy C., Camire, Rodney M., Arruda, Valder R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2009
Soggetti:
Thrombosis and Hemostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925478/
https://ncbi.nlm.nih.gov/pubmed/19770361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-220327
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