The immunogenicity of platelet-derived FVIII in hemophilia A mice with or without preexisting anti-FVIII immunity

Evidence shows that factor VIII (FVIII) ectopically expressed in platelets (2bF8) is therapeutic in FVIII(null) mice even with anti-FVIII inhibitory antibodies (inhibitors). If current efforts to generate platelets in vitro succeed, genetically manipulated platelets containing FVIII may be used ther...

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Опубликовано в: :Blood
Главные авторы: Chen, Yingyu, Schroeder, Jocelyn A., Chen, Juan, Luo, Xiaofeng, Baumgartner, Christina K., Montgomery, Robert R., Hu, Jianda, Shi, Qizhen
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2016
Предметы:
Thrombosis and Hemostasis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786841/
https://ncbi.nlm.nih.gov/pubmed/26668132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-08-662916
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