Platelet gene therapy corrects the hemophilic phenotype in immunocompromised hemophilia A mice transplanted with genetically manipulated human cord blood stem cells

Lignende værker

• Factor IX ectopically expressed in platelets can be stored in α-granules and corrects the phenotype of hemophilia B mice
  af: Zhang, Guowei, et al.
  Udgivet: (2010)
• Targeting FVIII expression to endothelial cells regenerates a releasable pool of FVIII and restores hemostasis in a mouse model of hemophilia A
  af: Shi, Qizhen, et al.
  Udgivet: (2010)
• The immunogenicity of platelet-derived FVIII in hemophilia A mice with or without preexisting anti-FVIII immunity
  af: Chen, Yingyu, et al.
  Udgivet: (2016)
• In vivo enrichment of genetically manipulated platelets for murine hemophilia B gene therapy
  af: Chen, Yingyu, et al.
  Udgivet: (2020)
• Platelet-targeted hyperfunctional FIX gene therapy for hemophilia B mice even with preexisting anti-FIX immunity
  af: Schroeder, Jocelyn A., et al.
  Udgivet: (2021)