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Factor IX ectopically expressed in platelets can be stored in α-granules and corrects the phenotype of hemophilia B mice
We developed 2bF9 transgenic mice in a hemophilia B mouse model with the expression of human factor IX (FIX) under control of the platelet-specific integrin αIIb promoter, to determine whether ectopically expressing FIX in megakaryocytes can enable the storage of FIX in platelet α-granules and corre...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2938234/ https://ncbi.nlm.nih.gov/pubmed/20445020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-255612 |
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