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Factor IX ectopically expressed in platelets can be stored in α-granules and corrects the phenotype of hemophilia B mice

We developed 2bF9 transgenic mice in a hemophilia B mouse model with the expression of human factor IX (FIX) under control of the platelet-specific integrin αIIb promoter, to determine whether ectopically expressing FIX in megakaryocytes can enable the storage of FIX in platelet α-granules and corre...

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Détails bibliographiques
Auteurs principaux: Zhang, Guowei, Shi, Qizhen, Fahs, Scot A., Kuether, Erin L., Walsh, Christopher E., Montgomery, Robert R.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2010
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938234/
https://ncbi.nlm.nih.gov/pubmed/20445020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-255612
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