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The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression
Previous studies have shown that platelet-specific factor VIII (FVIII) expression (2bF8) restores hemostasis and induces immune tolerance in hemophilia A (HA) mice even with preexisting inhibitors. Here we investigated for the first time whether platelet FVIII expression can prevent severe spontaneo...
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| Publicado no: | Blood Adv |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6960468/ https://ncbi.nlm.nih.gov/pubmed/31899798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000944 |
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